MayoClinic.com网站称，安非他酮是一种用于治疗抑郁症和帮助人们戒烟的药物。一定要按照医生的指示使用安非他酮，不要超过处方剂量，以免产生副作用。建议在服用安非他酮时避免咖啡因等兴奋剂，因为兴奋剂有时会增强安非他酮的副作用。
安非他酮和咖啡因的相互作用
1998年发表在《药理学、生物化学和行为》(Pharmacology, Biochemistry and Behavior)上的一项研究测试了安非他酮(bupropion)等抗抑郁药对低活性繁殖的大鼠的影响。The study made use of rat test subjects that were given bupropion and other antidepressants subcutaneously for 1, 12 or 26 days. The rats were then tested for activity in a swim test. Non-antidepressants like caffeine were also tested on the rats to provide a basis of comparison. The results showed that the rats in the group receiving the antidepressant medications like bupropion for at least 14 days were more likely to struggle or actively attempt to escape the water when subjected to the swim test. Long-term administration also reduced the rats' tendency to float in the water passively during the swim test. More testing is necessary to establish whether the same effects will occur among humans. Although caffeine has not been associated with direct interaction with bupropion, consult your doctor about your caffeine intake before taking bupropion, the University of Maryland Medical Center says.
滥用的风险
任何进入大脑并激活大脑愉悦中心的药物都有可能被滥用。激活快乐中心会引起欣快感和其他愉悦效果，这可能会使一些人上瘾。发表在2004年4月号《药理学》上的一项研究表明，安非他酮和咖啡因都能刺激大脑，可能会被寻求药物快感的瘾君子滥用。结合使用这两种药物可能会增加大脑愉悦中枢的激活，增加被滥用的风险。
安非他酮副作用
MayoClinic.com网站指出，安非他酮的使用会导致焦虑、口干、过度通气、心律失常、易怒、失眠和气短等副作用。皮疹、严重头痛和耳鸣被认为是不常见的副作用。高咖啡因摄入有时也会引起类似的效果。服用安非他酮时摄入咖啡因可能会增加副作用的风险。
咖啡因的副作用
马里兰大学医学中心指出，每天摄入超过250毫克的咖啡因会增加出现不良反应的风险，如心率加快、排尿过多、恶心、呕吐、烦躁不安、失眠以及焦虑和抑郁。突然停止摄入咖啡因有时会导致头痛、嗜睡和易怒等症状。